1 In a study of 92 patients with suspected HIT, 28 patients tested positive and 2 tested inconclusive for HIT antibodies using the PIFA Heparin/PF4 Rapid Assay. All patients with a negative result using PIFA, also had a negative result with SRA testing.
(Source: Andrews, et al. Critical Care 2013, 17:R143. “Prospective observational evaluation of the particle immunofiltration anti platelet factor 4 rapid assay in MICU patients with thrombocytopenia.” http://ccforum.com/content/17/4/R143). Separately, in tests done by outside laboratories, comparison to a standard, commercially available ELISA technique showed that the PIFA test had a specificity of 98.1%, sensitivity of 91.3%, and overall agreement in 97.2% of samples originating from field sources (n=179). This information is available in the PIFA PLUSS® PF4 and PIFA® Heparin/PF4 product inserts, available at www.akersbiosciences.com.
2 Source: Kaiser Family Foundation, average hospital adjusted expenses per inpatient day in 2012: $2,090 (http://kff.org/other/state indicator/expenses per inpatient day/accessed March 1, 2015)
3 Typical send-out ELISA costs range from $80 to $200 per test. Your costs may vary.
4 Contact you distributor for actual pricing.
5 Test Results Turn around Time (TAT) less than 1 hour.
6 This amount only accounts for suspected HIT patients that are currently tested for HIT antibodies. Some clinicians may forgo testing due to long turnaround time, send out costs, or clinical reasons.
7 Calculation assumes that patients with neg (-) results from PIFA HIT antibody test are not placed on DTIs, and those with positive PIFA results will placed on DTIs for period of time equivalent to the turnaround time for confirming ELISA or SRA test.
8 The PIFA Heparin test is a negative rule out test for HIT antibodies. The estimate above is based on roughly 2 out of 3 (67%) HIT suspected patients receiving a DTI negative (-) PIFA result, and the attending clinician subsequently choosing to not switch these patients to DTI therapy. Anticoagulant decisions should made by qualified clinicians with consideration of all appropriate information.